The new 32-storey Wyndham Cardiff hotel, which is currently being built, will be the tallest hotel in Wales on its completion in 2013.
The £60m ($89.3m) hotel will be operated by Wyndham Hotel Group under a joint venture management agreement with CHI Hotels & Resorts of Malta.
Bayscape will deliver the 127m-high hotel, which will be connected to Pont y Werin footbridge with a walkway.
The 200-room hotel features an additional 35 serviced apartments, 3,600m² of function space, an indoor pool, sauna, whirlpool, fitness centre and spa.
Dining options include a health bar, cafe and signature bar and restaurant on the 24th and 25th floors, the company said.
In addition, the project will include development of 100 residential units, shops, offices and businesses overlooking the marina and the Cardiff International White Water centre.
This will be the third hotel in Europe from Wyndham Hotel Group, which owns 7,100 luxury hotels and 11 brands across the world.