The eight-story Hilton hotel will be spread across an area of 179,000ft2.
The hotel will feature 252 guest rooms and other guest amenities including a fitness centre, on-site restaurant with room service and an outdoor pool.
Additionally, it will boast 16,000ft2 of meeting space, including a flexible main ballroom and a junior ballroom, three additional smaller meeting rooms and 5,000ft2 outdoor patio space for various events.
Construction on the $70m hotel is slated to commence in the summer of next year with an aim to complete it by early 2024.
Concord Hospitality president and CEO Mark Laport said: “Mayo Clinic in Florida provides critical care to hundreds of thousands of patients every year, making this project all the more special and important to us.
The new hotel, which is expected to join Hilton’s flagship brand, Hilton Hotels & Resorts, will be Concord Hospitality’s fourth property in Jacksonville and its 27th hotel in Florida.
About 85 full-time and 40 part-time jobs are expected to be created after the project’s completion.
Whitman Peterson and Concord Hospitality have already partnered on more than 20 projects that are open or under construction since 2016.
Whitman Peterson managing director Paul Novak said: “I had the privilege of developing another hotel on the campus over 35 years ago and now our partnership is bringing a whole new lodging facility to this world-class medical complex.
“We are so thrilled that this hotel will be a full-service Hilton with some remarkable facilities and amenities.”